博格德生物

Biogoethe

BGD6078

Recombinant Varicella-zoster virus Envelope glycoprotein E(gE)

20μg

15000

15000

可加减数量

可放入购物车

博格德生物

Biogoethe

BGD6079

Recombinant Varicella-zoster virus Envelope glycoprotein E(gE)

100μg

23000

23000

可加减数量

可放入购物车

基因名

gE

Uniprot No.

P09259

别名

gE; ORF68; Envelope glycoprotein E; gE

种属

Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3)

蛋白长度

Full Length of Mature Protein

来源

in vitro E.coli expression system

分子量

85.4 kDa

表达区域

31-623aa

氨基酸序列

SVLRYDDFHTDEDKLDTNSVYEPYYHSDHAESSWVNRGESSRKAYDHNSPYIWPRNDYDGFLENAHEHHGVYNQGRGIDSGERLMQPTQMSAQEDLGDDTGIHVIPTLNGDDRHKIVNVDQRQYGDVFKGDLNPKPQGQRLIEVSVEENHPFTLRAPIQRIYGVRYTETWSFLPSLTCTGDAAPAIQHICLKHTTCFQDVVVDVDCAENTKEDQLAEISYRFQGKKEADQPWIVVNTSTLFDELELDPPEIEPGVLKVLRTEKQYLGVYIWNMRGSDGTSTYATFLVTWKGDEKTRNPTPAVTPQPRGAEFHMWNYHSHVFSVGDTFSLAMHLQYKIHEAPFDLLLEWLYVPIDPTCQPMRLYSTCLYHPNAPQCLSHMNSGCTFTSPHLAQRVASTVYQNCEHADNYTAYCLGISHMEPSFGLILHDGGTTLKFVDTPESLSGLYVFVVYFNGHVEAVAYTVVSTVDHFVNAIEERGFPPTAGQPPATTKPKEITPVNPGTSPLLRYAAWTGGLAAVVLLCLVIFLICTAKRMRVKAYRVDKSPYNQSMYYAGLPVDDFEDSESTDTEEEFGNAIGGSHGGSSYTVYIDKTR

Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.

蛋白标签

N-terminal 10xHis-SUMO-tagged

产品提供形式

Liquid or Lyophilized powder

Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

缓冲液

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0

储存条件

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

保质期

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.

Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

货期

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

注意事项

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

基因功能参考文献

·  Expression and glycan processing of VZV gE were decreased after ATG5 knockdown. PMID: 24198400

·  gE gene sequences revealed a novel non-synonymous mutations in the e1 and c1 epitopes. PMID: 23757839

·  GE/gI interaction is critical for VZV neurovirulence. PMID: 20962081

·  data show that the nonconserved N-terminal region of varicella-zoster virus glycoprotein E is required for VZV tropism for T cells and skin, which is necessary for its life cycle in the human host PMID: 19966293

·  The precursor nonglycosylated gE form (73 kDa) found in the endoplasmic reticulum binds to Insulin-degrading enzyme. PMID: 19864391

·  C-terminal domain of varicella-zoster virus glycoprotein E plays a role in viral replication in vitro and skin and T-cell tropism in vivo. PMID: 15507627

·  HSV deleted for glycoprotein E is impaired for cell-to-cell spread, and VZV gE could not complement this activity. PMID: 19233447

亚细胞定位

Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host cell junction. Host Golgi apparatus membrane; Single-pass membrane protein. Host endosome membrane; Single-pass membrane protein.

蛋白家族

Alphaherpesvirinae glycoprotein E family

数据库链接

KEGG: vg:1487709